AD 210: Having suffered heavy losses since invading Scotland in 208, Emperor Septimius Severus sends his son - Caracalla - to systematically wipe out and torture the Scots into submission.
AD 213: Cao Cao, the prime minister of the Han dynasty, is titled Wei Gong (Duke of Wei) and given a fief of ten cities under his domain.[2] This later becomes the Kingdom of Wei.
AD 215: Caracalla's troops massacre the population of Alexandria, Egypt,[1] beginning with the leading citizens. The emperor was angry about a satire, produced in Alexandria, mocking his claim that he killed Geta in self-defense.
AD 218: The silver content of the Roman denarius falls to 43 percent under the reign of Elagabalus, down from 50 percent under Septimius Severus, as he empties the treasury.
AD 221: May 15 – Liu Bei, Chinese warlord and descendant of the imperial clan of the Han dynasty, proclaims himself emperor in Chengdu, Sichuan, and establishes the state of Shu Han.
AD 226: A merchant from the Roman Empire, called "Qin Lun" by the Chinese, arrives in Jiaozhi (modern Hanoi), and is taken to see King Sun Quan of Eastern Wu, who requests him to make a report on his native country and people. He is given an escort for the return trip, including a present of ten male and ten female "blackish-colored dwarfs." However, the officer in charge of the Chinese escort dies, and Qin Lun has to continue his journey home alone.[1]
AD 230: Emperor Alexander Severus decides that Thessaly should be a separate province from Macedonia. He increases taxes, in order to maintain the war against the Sassanids, and strengthen the defenses of the Roman Empire.
AD 240: The Roman Empire is threatened on several fronts at the same time. Africa revolts and tribes in northwest Germania, under the name of the Franks, are raiding the Rhine frontier.