AD 604: August 13 – Emperor Wéndi dies, age 63, presumably assassinated by his son Yángdi, after a 23-year reign in which he has attacked hereditary privilege and reduced the power of the military aristocracy. He is succeeded by Yángdi, who becomes the second emperor of the Sui dynasty.
AD 605: Amshuvarma becomes king of the Licchavi in Nepal. He is credited for opening trade routes to Tibet. His ruling period is known as the "Golden Period".
AD 609: Emperor Yángdi completes the Grand Canal; it provides an unbroken inland ship transport between the Yellow and Yangtze rivers. The canal network is 1,776 km (1,400 miles) long—linking five river systems—and extends from Beijing to the city of Hangzhou.
AD 615: The Anglo-Saxons, under King Æthelfrith of Northumbria, after defeating the Kingdom of Powys, finally reach the Irish Sea and massacre 1,200 Christian monks at their monastery, in Bangor (Wales).
AD 618: November 8 – Pope Adeodatus I dies in Rome after a 3-year reign, in which he has reversed the policies of his predecessors, Boniface IV and Gregory I, who favored monks over the secular clergy. Adeodatus will not be replaced until next year.