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AD 653: Emperor Kōtoku sends an embassy to the court of the Tang dynasty in China. Japanese ambassadors, priests and students sail for the capital Chang'an, but some of the ships are lost en route.

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AD 651: The Hôtel-Dieu de Paris is founded by bishop Landry (Landericus). It becomes the first major hospital in Paris.

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AD 649: Arab–Byzantine War: Arab naval forces under Abdullah ibn Saad conquer Cyprus, sacking the capital Constantia after a short siege, and looting the rest of the island. The Cypriots agree to pay the same revenue as they have done to Emperor Constans II.

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AD 647: A stone tower astronomical observatory (named Cheomseongdae) at Gyeongju is constructed in Silla (South Korea) around this time.

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AD 645: Alexandria revolts against Arab rule, at the appearance of a Byzantine fleet of 300 ships, and Byzantine forces recapture the city. Abdullah ibn Sa'ad, Arab governor of Egypt, mounts an assault and retakes it. He begins building a Muslim fleet.

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